Article
The effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.
Molecular biology of the cell - 1 Jan 1994
Carlberg K, Rohrschneider L
Abstract excerpt
Oncogenic activation of the macrophage colony stimulating factor (M-CSF) receptor (c-Fms) requires mutation or truncation of the carboxyl terminus and specific amino acid substitutions in or near the fourth immunoglobulin (Ig)-like loop in the extracellular domain. Using a murine c-Fms system, we...
Topics
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Endocytosis
- Mice
- Mutagenesis, Site-Directed
- Mutation
- Oncogene Protein gp140(v-fms)
- Phosphorylation
- Phosphotyrosine
- Protein Conformation
- Protein Processing, Post-Translational
- Protein-Tyrosine Kinases
- Rabbits
- Rats
- Receptor, Macrophage Colony-Stimulating Factor
- Recombinant Fusion Proteins
- Tyrosine