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Article

Molecular alterations associated with liver metastases development in colorectal cancer patients.

British journal of cancer - 12 Jul 2011

Bruin S C, He Y, Mikolajewska-Hanclich I, Liefers G-J, Klijn C, Vincent A, Verwaal V J, de Groot K A, Morreau H, van Velthuysen M-L F, Tollenaar R A E M, van 't Veer L J

Abstract excerpt

BACKGROUND: Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predict liver metastases. METHODS: Formalin-fixed paraffin-embedded material from primary colorectal...

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Identifiers

PMID: 21673680
DOI: 10.1038/bjc.2011.184
PMCID: PMC3142796

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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