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Article

PI3K expression and PIK3CA mutations are related to colorectal cancer metastases.

World journal of gastroenterology - 28 Jul 2012

Zhu Yu-Fen, Yu Bao-Hua, Li Da-Li, Ke Hong-Lin, Guo Xian-Zhi, Xiao Xiu-Ying

Abstract excerpt

AIM: To assess the significance of phosphatidylinositol 3-kinase (PI3K) in colorectal cancer (CRC) and toxicity of LY294002 in CRC cells with different metastatic abilities. METHODS: Sixty formalin-fixed and paraffin-embedded CRC tumor specimens were investigated. Adjacent normal colonic mucosa specimens from 10 of these cases were selected as controls. PI3K protein was detected by immunohistochemistry and PIK3CA...

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Identifiers

PMID: 22851869
DOI: 10.3748/wjg.v18.i28.3745
PMCID: PMC3406429

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Source receipt: pubmed, retrieved 7 Sept 2026.

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