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Article

Oncogenic <i>PIK3CA</i> mutations in colorectal cancers and polyps

19 Sept 2011

Abstract excerpt

Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor therapy for advanced colorectal cancer, although studies have been conflicting. We sought to...

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Share to Colorectal Cancer Treatments and Studies
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Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21932420
DOI: 10.1002/ijc.26440

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