Article
PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival.
PloS one - 1 Jan 2013
Rosty Christophe, Young Joanne P, Walsh Michael D, Clendenning Mark, Sanderson Kristy, Walters Rhiannon J, Parry Susan, Jenkins Mark A, Win Aung Ko, Southey Melissa C, Hopper John L, Giles Graham G, Williamson Elizabeth J, English Dallas R, Buchanan Daniel D
Abstract excerpt
Mutations in PIK3CA are present in 10 to 15% of colorectal carcinomas. We aimed to examine how PIK3CA mutations relate to other molecular alterations in colorectal carcinoma, to pathologic phenotype and survival. PIK3CA mutation testing was carried out using direct sequencing on 757 incident tumors from the Melbourne Collaborative Cohort Study. The status of O-6-methylguanine-DNA methyltransferase (MGMT) was...
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