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Article

Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers.

Journal of surgical oncology - 1 Jun 2015

Lan Yuan-Tzu, Jen-Kou Lin, Lin Chien-Hsing, Yang Shung-Haur, Lin Chun-Chi, Wang Huann-Sheng, Chen Wei-Shone, Lin Tzu-Chen, Jiang Jeng-Kai, Chang Shih-Ching

Abstract excerpt

BACKGROUND AND OBJECTIVES: Identification of mutations in the downstream epidermal growth factor receptor (EGFR) signaling pathway could provide important insights of EGFR-targeted therapies in colorectal cancers. We analyzed the mutation spectra of the PI3K/PTEN/AKT and RAS/RAF/MAPK pathways in colorectal cancers and the associations of these mutations with sites of metastases or recurrence. METHODS: The study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25920435
DOI: 10.1002/jso.23895

Genes

EGFR
NRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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