Article
Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2.
BMC cancer - 13 Sept 2004
Miller A Dusty, Van Hoeven Neal S, Liu Shan-Lu
Abstract excerpt
BACKGROUND: The envelope (Env) protein of jaagsiekte sheep retrovirus (JSRV) can transform cells in culture and is likely to be the main factor responsible for lung cancer induction by JSRV in animals. A recent report indicates that the epithelial-cell transforming activity of JSRV Env depends on activation of the cell-surface receptor tyrosine kinase Mst1r (called RON for the human and Stk for the rodent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.