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Article

Molecular and functional analysis of tumor-suppressor genes by transfection.

Environmental health perspectives - 1 Jun 1991

Schäfer R, Iyer J, Iten E, Nirkko A C, Balmer J, Klemenz R

Abstract excerpt

The transformed and tumorigenic phenotype of H-ras transfected rat FE-8 cells can be suppressed by cell fusion with normal rat embryo fibroblasts. Transfection into FE-8 cells of DNA prepared from normal human placenta followed by selective elimination of tumorigenic transfected cell clones resulted in the isolation of phenotypically normal revertants. These cells exhibited a fibroblastlike, normal morphology;...

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Identifiers

PMID: 1773805
DOI: 10.1289/ehp.93-1568050
PMCID: PMC1568050

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NTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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