Article

RNA-mediated Genomic Arrangements in Mammalian Cells

2017-06-16

Abstract excerpt

<h4>Summary</h4> One of the hallmarks of cancer is the formation of oncogenic fusion genes as a result of chromosomal translocations. Fusion genes are presumed to occur prior to fusion RNA expression. However, studies have reported the presence of fusion RNAs in individuals who were negative for chromosomal translocations. These observations give rise to “the cart before the horse” hypothesis, in which fusion RNA...

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Literature Corpus work: f6f8bab6-8b7b-57e9-b3f7-644413900a70
DOI: 10.1101/151241

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