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Article

A 3' truncation of myc caused by chromosomal translocation in a human T-cell leukemia is tumorigenic when tested in established rat fibroblasts.

Oncogene - 1 Dec 1991

Aghib D F, Bishop J M

Abstract excerpt

We have previously identified in human T-leukemia cells a myc gene with an unusual 3' rearrangement, and we have shown that expression of the gene is deregulated by stabilization of mRNA. Here we report that the rearranged gene transforms established rat fibroblasts to a tumorigenic phenotype. In hybrid genes, the transforming capability segregates with the 3' rearrangement. Transformation is apparently due to a...

Topics

Alleles
Animals
Cell Division
Cell Line
Cell Transformation, Neoplastic
Fibroblasts
Gene Rearrangement
Genes, myc
Humans
Leukemia, T-Cell
RNA, Messenger
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Translocation, Genetic

Source

Identifiers

PMID: 1766681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1766681-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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