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Article

Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter.

BMC cancer - 10 Jun 2011

Dávalos-Salas Mercedes, Furlan-Magaril Mayra, González-Buendía Edgar, Valdes-Quezada Christian, Ayala-Ortega Erandi, Recillas-Targa Félix

Abstract excerpt

BACKGROUND: Long-term gene silencing throughout cell division is generally achieved by DNA methylation and other epigenetic processes. Aberrant DNA methylation is now widely recognized to be associated with cancer and other human diseases. Here we addressed the contribution of the multifunctional nuclear factor CTCF to the epigenetic regulation of the human retinoblastoma (Rb) gene promoter in different tumoral...

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Identifiers

PMID: 21663659
DOI: 10.1186/1471-2407-11-232
PMCID: PMC3145615

Genes

CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter.PMID 21663659Read ↗

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