Article

CTCF Expression Is Essential for Somatic Cell Viability and Protection against Cancer

2018-10-19

Abstract excerpt

CCCTC-binding factor (CTCF) is a conserved transcription factor that performs diverse roles in transcriptional regulation and chromatin architecture. Cancer genome sequencing reveals diverse acquired mutations in CTCF, which we have shown, functions as a tumour suppressor gene. While CTCF is essential for embryonic development, little is known of its absolute requirement in somatic cells and the consequences of CT...

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Literature Corpus work: af41e438-a7f1-5a30-8fda-3093b9f55458
DOI: 10.20944/preprints201810.0451.v1

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