Article
Cytosine methylation transforms an E2F site in the retinoblastoma gene promoter into a binding site for the general repressor methylcytosine-binding protein 2 (MeCP2).
Nucleic acids research - 15 Jul 1999
Di Fiore B, Palena A, Felsani A, Palitti F, Caruso M, Lavia P
Abstract excerpt
The CpG-rich promoter of the retinoblastoma tumor suppressor gene (Rb-1) is normally unmethylated. However, aberrant methylation of CpG dinucleotides within the Rb-1 promoter has been depicted in certain tumors, which determines transcriptional inactivity of the gene and absence of the pRb retinoblastoma protein. Here we have concentrated on an E2F-binding site in the Rb-1 promoter. We show that the E2F site is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.