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Article

Visualizing dynamic E2F-mediated repression in vivo.

Molecular and cellular biology - 1 Jun 2006

Agromayor Monica, Wloga Elzbieta, Naglieri Benedetta, Abrashkin John, Verma Kapil, Yamasaki Lili

Abstract excerpt

Although many E2F target genes have been identified recently, very little is known about how any single E2F site controls the expression of an E2F target gene in vivo. To test the requirement for a single E2F site in vivo and to learn how E2F-mediated repression is regulated during development and tumorigenesis, we have constructed a novel series of wild-type and mutant Rb promoter-LacZ transgenic reporter lines...

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Identifiers

PMID: 16738312
DOI: 10.1128/MCB.02101-05
PMCID: PMC1489115

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