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Article

Detection of Aberrant DNA Methylation Patterns in the RB1 Gene.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Anwar Sumadi Lukman, Lehmann Ulrich

Abstract excerpt

The retinoblastoma protein (pRb) plays a central role in the regulation of cell cycle by interaction with members of the E2F transcription factor family. As a tumor suppressor protein, pRb is frequently dysregulated in several major cancers. In addition to mutations, inactivation of pRb is also caused by epigenetic mechanisms including alterations of DNA methylation. There are three CpG islands located within the...

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Identifiers

PMID: 29468542
DOI: 10.1007/978-1-4939-7565-5_5

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