Article
Distinct gene expression phenotypes of cells lacking Rb and Rb family members.
Cancer research - 1 Jul 2003
Black Esther P, Huang Erich, Dressman Holly, Rempel Rachel, Laakso Nina, Asa Sylvia L, Ishida Seiichi, West Mike, Nevins Joseph R
Abstract excerpt
The study of tumor suppressor gene function has been aided by the creation of discrete gene alterations in the mouse. One such example can be seen in the study of tumor suppressor gene function in general and the retinoblastoma (Rb) tumor suppressor in particular. Because the phenotype of a cell is a direct reflection of the gene activity within that cell, a comprehensive analysis of changes in gene activity...
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