Article

Functional divergence of DSCAM family in vertebrates through domain-specific evolutionary pressures

2026-04-15

Abstract excerpt

The Down syndrome cell adhesion molecule (DSCAM) family, conserved across metazoans, plays key roles in neural development by mediating cell-cell recognition. Invertebrate Dscam evolved extensive molecular diversity through isoform diversification, whereas the vertebrate paralogs DSCAM and DSCAML1 followed a distinct evolutionary trajectory. However, how these vertebrate paralogs evolved after duplication, particu...

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Literature Corpus work: 49136c1e-cb5b-5a96-92c2-7a6f8be50772
DOI: 10.64898/2026.04.14.718097

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