Article
XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.
Environmental and molecular mutagenesis - 1 Jul 2007
Fan Jinshui, Wilson Paul F, Wong Heng-Kuan, Urbin Salustra S, Thompson Larry H, Wilson David M
Abstract excerpt
Previous studies using rodent cells indicate that a deficiency in XRCC1 results in reduced single-strand break repair, increased sensitivity to DNA-damaging agents, and elevated levels of sister chromatid exchange (SCE). Epidemiological studies have suggested an association of certain human XRCC1 polymorphisms with genetic instability and cancer susceptibility. However, investigations on the molecular functions...
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