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Article

Frequent loss of heterozygosity at 11p loci in testicular cancer.

The Journal of urology - 1 May 1995

Smith R C, Rukstalis D B

Abstract excerpt

Deletions of segments of chromosome 11 have been found to be involved in several human tumors. Specific deletion of chromosomal band 11p13 has been associated with Wilms' tumors and gonadoblastomas. We performed a deletion analysis of 11p using 6 polymorphic probes and DNA from 30 testicular mali...

Topics

Adult
Aged
Alleles
Blotting, Northern
Blotting, Southern
Cell Line
Chromosome Deletion
Chromosomes, Human, Pair 11
DNA, Complementary
Gene Deletion
Gene Dosage
Genes, Tumor Suppressor
Germinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Humans

Male

Seminoma

Testicular Neoplasms

Source

Identifiers

PMID: 7715010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7715010-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Frequent loss of heterozygosity at 11p loci in testicular cancer.PMID 7715010Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity on chromosome arms 5q, 11p, 11q, 13q, and 16p in human testicular germ cell tumors.Semantic proximity Read ↗

Allelotyping in Wilms tumors identifies a putative third tumor suppressor gene on chromosome 11.Semantic proximity Read ↗

Loss of heterozygosity identifies multiple sites of allelic deletions on chromosome 1 in human male germ cell tumors.Semantic proximity Read ↗

Loss of heterozygosity at 11p13 in Wilms' tumours does not necessarily involve mutations in the WT1 gene.Semantic proximity Read ↗

Direct pulsed field gel electrophoresis of Wilms' tumors shows that DNA deletions in 11p13 are rare.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11.Semantic proximity Read ↗

Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors.Semantic proximity Read ↗

Identification of differential methylation of the WT1 antisense regulatory region and relaxation of imprinting in Wilms' tumor.Semantic proximity Read ↗

Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.Semantic proximity Read ↗

Genetic mosaicism in normal tissues of Wilms' tumour patients.Semantic proximity Read ↗

Differences in patterns of allelic loss between two common types of adult cancer, breast and colon carcinoma, and Wilms' tumor of childhood.Semantic proximity Read ↗

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