Loss of heterozygosity for chromosome region 11p15 in Wilms' tumours is not related to HRAS gene transforming mutations.

Article

Loss of heterozygosity for chromosome region 11p15 in Wilms' tumours is not related to HRAS gene transforming mutations.

Oncogene - 1 Jul 1991

Baird P, Wadey R, Cowell J

Abstract excerpt

Although a candidate Wilms' tumour gene--WT1--has been identified in chromosome region 11p13, there is strong evidence from loss of heterozygosity studies suggesting that a second relevant gene is present in region 11p15. The Harvey-Ras proto-oncogene also lies in this region. In other types of t...

Topics

Base Sequence
Chromosomes, Human, Pair 11
Codon
DNA, Neoplasm
Exons
Genes, Wilms Tumor
Genes, ras
Heterozygote
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Proto-Oncogene Mas

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.