Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.

doi:10.1038/316330a0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.

Nature - 1 Jan 2000

Koufos A, Hansen M F, Copeland N G, Jenkins N A, Lampkin B C, Cavenee W K

Abstract excerpt

Children with the Beckwith-Wiedemann syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanism that entails the somatic development of homozygosity for a mutant allele at a...

Topics

Abnormalities, Multiple
Alleles
Animals
Carcinoma, Hepatocellular
Child
Child, Preschool
Chromosome Mapping
Chromosomes, Human, 6-12 and X
DNA, Neoplasm
Female
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Liver Neoplasms

Male

Mice

Mutation

Neoplasm Transplantation

Source

Open in PubMed

Identifiers

PMID: 2991766
DOI: 10.1038/316330a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2991766-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.PMID 2991766Read ↗

Concurrent Hepatoblastoma and Wilms Tumor Leading to Diagnosis of Beckwith-Wiedemann Syndrome.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11.Semantic proximity Read ↗

11p15.5 epimutations in children with Wilms tumor and hepatoblastoma detected in peripheral blood.Semantic proximity Read ↗

Genetic mosaicism in normal tissues of Wilms' tumour patients.Semantic proximity Read ↗

Constitutional mosaic genome-wide uniparental disomy due to diploidisation: an unusual cancer-predisposing mechanism.Semantic proximity Read ↗

Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.Semantic proximity Read ↗

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.Semantic proximity Read ↗

Genome-wide loss of maternal alleles in a nephrogenic rest and Wilms' tumour from a BWS patient.Semantic proximity Read ↗

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.Semantic proximity Read ↗

Genetics of Beckwith‐Wiedemann syndrome‐associated tumors: Common genetic pathwaysSemantic proximity Read ↗

Differences in patterns of allelic loss between two common types of adult cancer, breast and colon carcinoma, and Wilms' tumor of childhood.Semantic proximity Read ↗

Beckwith-Wiedemann syndrome, tumourigenesis and imprinting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.