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Article

Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis.

PloS one - 1 Jan 2011

Hedegaard Chris Juul, Enevold Christian, Sellebjerg Finn, Bendtzen Klaus, Nielsen Claus Henrik

Abstract excerpt

Variations in the gene for the nucleotide-binding oligomerisation domain (NOD) 2 have been associated with Crohn's disease but not multiple sclerosis (MS). Here we investigate the effect of three polymorphisms in the NOD2 gene (rs5743277, rs2066842 and rs5743291) on cytokine production and CD4+ T cell proliferation elicited by human myelin basic protein (MBP) in blood mononuclear cell (MNC) cultures from 29...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21625457
DOI: 10.1371/journal.pone.0020253
PMCID: PMC3098873

Genes

MBP
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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