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Article

NOD2 variants and the risk of malignant melanoma.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Apr 2005

Debniak T, Kurzawski G, Huzarski T, Byrski T, Gronwald J, Debniak B, Rozmiarek A, Dziuba I, Złowocka E, Suchy J, Górski B, Cybulski C, Mierzejewski M, Masojć B, Medrek K, Oszurek O, Lubiński J

Abstract excerpt

Both hereditary and environmental factors are important in the aetiology of malignant melanoma. Among the risk factors for malignant melanoma are immunodeficiency and immunosuppression. The recently identified NOD2 gene is involved in the regulation of immune function through activation of the transcription factor nuclear factor-kappaB (NF-kappaB). Three common NOD2 mutations -- 3020insC, G908R and R702W -- have...

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Identifiers

PMID: 15785318
DOI: 10.1097/00008469-200504000-00010

Genes

NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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