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Article

An IL-5 Single-Nucleotide Polymorphism Influences Neuroinflammation and Prospective Disease Activity in Multiple Sclerosis.

International journal of molecular sciences - 22 Aug 2024

Dolcetti Ettore, Buttari Fabio, Bruno Antonio, Azzolini Federica, Gilio Luana, Borrelli Angela, Di Caprio Veronica, Lauritano Gianluca, Galifi Giovanni, Gambardella Stefano, Ferese Rosangela, Giardina Emiliano, Rovella Valentina, Furlan Roberto, Finardi Annamaria, Musella Alessandra, Balletta Sara, Mandolesi Georgia, Centonze Diego, Stampanoni Bassi Mario

Abstract excerpt

(1) Multiple sclerosis (MS) is identified by a complex interaction between central inflammation and neurodegeneration. Genetic individual variability could play a significative role in clinical presentation. The interleukin-5 (IL-5) rs2069812 single-nucleotide polymorphism (SNP) seems to define the clinical course of Th2 autoimmune diseases, while its role in MS has never been investigated. (2) In a group of 230...

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Case-Control Studies
Cytokines
Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Neuroinflammatory Diseases

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39201794
DOI: 10.3390/ijms25169108
PMCID: PMC11354457

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