Association of nod‐like receptor protein‐3 single nucleotide gene polymorphisms and expression with the susceptibility to relapsing–remitting multiple sclerosis

Abstract excerpt

Nod-like receptor protein 3 (NLRP3) inflammasome is a multi-protein complex that controls the production of pro-inflammatory cytokines, IL-18 and IL-1β, through caspase-1 activation. These inflammatory cytokines play an important role in the development of multiple sclerosis (MS). The inflammasome NLRP3 gene variations and expression level have been suggested to affect the immune system activity. This...

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