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Article

Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease.

Genomics - 1 Apr 2003

Ogura Yasunori, Saab Lisa, Chen Felicia F, Benito Adalberto, Inohara Naohiro, Nuñez Gabriel

Abstract excerpt

Genetic variation in human Nod2 has been associated with susceptibility to Crohn's disease. The mouse Nod2 locus is located at chromosome 8 and composed of 12 exons, 11 of which encode the Nod2 protein. Sequence analysis of Nod2 from 45 different strains of Mus musculus and Mus spretus revealed extensive polymorphism involving all exons of Nod2. Of the 140 polymorphic sites identified, 68 were located in the...

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Identifiers

PMID: 12676561
DOI: 10.1016/s0888-7543(03)00027-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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