Article
Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways.
Clinical and experimental immunology - 1 Mar 2009
Brosbøl-Ravnborg A, Hvas C L, Agnholt J, Dahlerup J F, Vind I, Till A, Rosenstiel P, Höllsberg P
Abstract excerpt
Pattern recognition receptors (PRRs) are an integral part of the innate immune system and govern the early control of foreign microorganisms. Single nucleotide polymorphisms (SNPs) in the intracellular pattern recognition receptor nucleotide-binding oligomerization domain-containing protein (NOD2, nucleotide oligomerization domain 2) are associated with Crohn's disease (CD). We investigated the impact of NOD2...
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