Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.

doi:10.1002/ibd.21913

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Article

Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.

Inflammatory bowel diseases - 1 May 2012

Scharl Michael, Mwinyi Jessica, Fischbeck Anne, Leucht Katharina, Eloranta Jyrki J, Arikkat Joba, Pesch Theresa, Kellermeier Silvia, Mair Alma, Kullak-Ublick Gerd A, Truninger Kaspar, Noreen Faiza, Regula Jaroslaw, Gaj Pawel, Pittet Valerie, Mueller Christoph, Hofmann Claudia, Fried Michael, McCole Declan F, Rogler Gerhard

Abstract excerpt

BACKGROUND: The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis. We have previously shown that PTPN2 regulates mitogen-activated protein kinase (MAPK) signaling and cytokine secretion in human THP-1 monocytes...

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Identifiers

PMID: 22021207
DOI: 10.1002/ibd.21913

Genes

PTPN2
NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.PMID 22021207Read ↗

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