Article
Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.
PloS one - 26 May 2010
Fang Shenying, Krahe Ralf, Lozano Guillermina, Han Younghun, Chen Wei, Post Sean M, Zhang Baili, Wilson Charmaine D, Bachinski Linda L, Strong Louise C, Amos Christopher I
Abstract excerpt
BACKGROUND: Previous studies have shown that MDM2 SNP309 and p53 codon 72 have modifier effects on germline P53 mutations, but those studies relied on case-only studies with small sample sizes. The impact of MDM4 polymorphism on tumor onset in germline mutation carriers has not previously been studied. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed 213 p53 germline mutation carriers including 168(78.9%) affected...
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