Article
MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2007
Hu Zhibin, Jin Guangfu, Wang Lu, Chen Feng, Wang Xinru, Shen Hongbing
Abstract excerpt
Since the identification of a well-characterized functional polymorphism named SNP309 in MDM2, abundant studies were published in the last 2 years to evaluate the association between SNP309 and tumor risk in diverse populations. However, the results remain conflicting rather than conclusive. Because a single study may have been underpowered to detect the effect of low-penetrance genes, a quantitative synthesis to...
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