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Article

TP53 and MDM2 gene polymorphisms, gene-gene interaction, and hepatocellular carcinoma risk: evidence from an updated meta-analysis.

PloS one - 1 Jan 2013

Peng Qiliu, Lao Xianjun, Chen Zhiping, Lai Hao, Deng Yan, Wang Jian, Mo Cuiju, Sui Jingzhe, Wu Junrong, Zhai Limin, Yang Shi, Qin Xue, Li Shan

Abstract excerpt

BACKGROUND: The association between TP53 R72P and/or MDM2 SNP309 polymorphisms and hepatocellular carcinoma (HCC) risk has been widely reported, but results were inconsistent. To clarify the effects of these polymorphisms on HCC risk, an updated meta-analysis of all available studies was conducted. METHODS: Eligible articles were identified by search of databases including PubMed, Cochrane Library, EMBASE and...

Topics

Carcinoma, Hepatocellular
Confidence Intervals
Epistasis, Genetic
Ethnicity
Genetic Predisposition to Disease
Humans
Liver Neoplasms
Odds Ratio
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-mdm2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Publication Bias

Risk Factors

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 24376578
DOI: 10.1371/journal.pone.0082773
PMCID: PMC3871586

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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TP53 and MDM2 gene polymorphisms, gene-gene interaction, and hepatocellular carcinoma risk: evidence from an updated meta-analysis.PMID 24376578Read ↗

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