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Article

Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy.

Pediatric blood & cancer - 1 Sept 2011

Kamdar Kala Y, Krull Kevin R, El-Zein Randa A, Brouwers Pim, Potter Brian S, Harris Lynnette L, Holm Suzanne, Dreyer Zoann, Scaglia Fernando, Etzel Carol J, Bondy Melissa, Okcu M Fatih

Abstract excerpt

BACKGROUND: Neurocognitive impairment occurs in 20-40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and homocysteine elevation following methotrexate treatment. We evaluated the relationship between folate pathway polymorphisms and neurocognitive impairment after childhood ALL chemotherapy. PROCEDURE: Seventy-two childhood ALL survivors treated with chemotherapy...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Attention Deficit Disorder with Hyperactivity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Metabolic Networks and Pathways

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

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Identifiers

PMID: 21618410
DOI: 10.1002/pbc.23162
PMCID: PMC3134130

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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