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Article

Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans.

Drug metabolism and personalized therapy - 1 Mar 2016

Gutiérrez-Álvarez Ossyneidee, Lares-Asseff Ismael, Galaviz-Hernández Carlos, Reyes-Espinoza Elio-Aarón, Almanza-Reyes Horacio, Sosa-Macías Martha, Chairez Hernández Isaías, Salas-Pacheco José-Manuel, Bailón-Soto Claudia E

Abstract excerpt

BACKGROUND: Folate metabolism plays an essential role in the processes of DNA synthesis and methylation. Deviations in the folate flux resulting from single-nucleotide polymorphisms in genes encoding folate-dependent enzymes may affect the susceptibility to leukemia. This case-control study aimed to assess associations among MTHFR (C677T, A1298C) and TPMT (*2, *3A) mutations as well as to evaluate the synergistic...

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Source

Identifiers

PMID: 26845729
DOI: 10.1515/dmpt-2015-0036

Genes

MTHFR
TPMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans.PMID 26845729Read ↗

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