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Article

Polymorphisms in Genes Related to Oxidative Stress Are Associated With Inferior Cognitive Function After Therapy for Childhood Acute Lymphoblastic Leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2015

Cole Peter D, Finkelstein Yaron, Stevenson Kristen E, Blonquist Traci M, Vijayanathan Veena, Silverman Lewis B, Neuberg Donna S, Sallan Stephen E, Robaey Philippe, Waber Deborah P

Abstract excerpt

PURPOSE: Survivors of childhood acute lymphoblastic leukemia (ALL) exhibit increased rates of neurocognitive deficits. This study was conducted to test whether interpatient variability in neurocognitive outcomes can be explained by polymorphisms in candidate genes conferring susceptibility to neurocognitive decline. METHODS: Neurocognitive testing was conducted in 350 pediatric leukemia survivors, treated on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25987702
DOI: 10.1200/JCO.2014.59.0273
PMCID: PMC4477790

Genes

NOS3
COMT
GSTP1

Provenance

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