Article

Phenotype-Specific Pharmacogenetic Patterns of Methotrexate Neurotoxicity in Pediatric Acute Lymphoblastic Leukemia

2026-07-29

Abstract excerpt

<h4>Background: </h4> Methotrexate-induced neurotoxicity (MTX-NTX) is a severe complication during childhood acute lymphoblastic leukemia (ALL) treatment, yet its underlying pharmacogenetic determinants remain incompletely understood. <h4>Methods:</h4> A multicenter retrospective nationwide case-control study was performed including 71 pediatric ALL patients (34 MTX-NTX cases and 37 controls). Targeted next-genera...

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Literature Corpus work: 89be48f2-30f9-51cc-9a6a-82deee1228b1
DOI: 10.20944/preprints202607.2171.v1

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