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Article

PIK3CA mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression.

Breast cancer research and treatment - 1 Sept 2011

Kalinsky Kevin, Heguy Adriana, Bhanot Umeshkumar K, Patil Sujata, Moynahan Mary Ellen

Abstract excerpt

PIK3CA gene mutations are the most common activating mutations in human breast cancer. Its association with hormone receptor-positive breast cancer makes it a prime target for clinical therapeutic advances to maintain anti-estrogen responsiveness. In anticipation of this therapeutic approach, we have evaluated intratumoral heterogeneity in primary breast cancers with regard to PIK3CA mutation status. In addition,...

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PMID: 21617917
DOI: 10.1007/s10549-011-1601-4

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AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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