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Genetic Heterogeneity in HER2 Testing in Breast Cancer: Panel Summary and Guidelines

1 Apr 2009

Abstract excerpt

CONTEXT: Intratumoral heterogeneity of HER2 gene amplification has been well documented and represents subclonal diversity within the tumor. The reported incidence of intratumor HER2 amplification genetic heterogeneity ranges in the literature from approximately 5% to 30%. The presence of HER2 genetic heterogeneity may increase subjectivity in HER2 interpretation by the pathologist. OBJECTIVES: To define HER2...

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PMID: 19391661
DOI: 10.5858/133.4.611

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