Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones.

doi:10.1172/JCI143557

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Article

Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones.

The Journal of clinical investigation - 15 Mar 2021

Karthikeyan Swathi, Waters Ian G, Dennison Lauren, Chu David, Donaldson Joshua, Shin Dong Ho, Rosen D Marc, Gonzalez-Ericsson Paula I, Sanchez Violeta, Sanders Melinda E, Pantone Morgan V, Bergman Riley E, Davidson Brad A, Reed Sarah C, Zabransky Daniel J, Cravero Karen, Kyker-Snowman Kelly, Button Berry, Wong Hong Yuen, Hurley Paula J, Croessmann Sarah, Park Ben Ho

Abstract excerpt

Intratumor heterogeneity is an important mediator of poor outcomes in many cancers, including breast cancer. Genetic subclones frequently contribute to this heterogeneity; however, their growth dynamics and interactions remain poorly understood. PIK3CA and HER2 alterations are known to coexist in breast and other cancers. Herein, we present data that describe the ability of oncogenic PIK3CA mutant cells to induce...

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PMID: 33529175
DOI: 10.1172/JCI143557
PMCID: PMC7954606

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