Article
Streptomycin resistance and lineage-specific polymorphisms in Mycobacterium tuberculosis gidB gene.
Journal of clinical microbiology - 1 Jul 2011
Spies Fernanda S, Ribeiro Andrezza W, Ramos Daniela F, Ribeiro Marta O, Martin Anandi, Palomino Juan Carlos, Rossetti Maria Lucia R, da Silva Pedro Eduardo A, Zaha Arnaldo
Abstract excerpt
Mutations related to streptomycin resistance in the rpsL and rrs genes are well known and can explain about 70% of this phenotypic resistance. Recently, the gidB gene was found to be associated with low-level streptomycin resistance in Mycobacterium tuberculosis. Mutations in gidB have been reported with high frequency, and this gene appears to be very polymorphic, with frameshift and point mutations occurring in...
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