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Article

Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.

Molecular microbiology - 1 Feb 2007

Okamoto Susumu, Tamaru Aki, Nakajima Chie, Nishimura Kenji, Tanaka Yukinori, Tokuyama Shinji, Suzuki Yasuhiko, Ochi Kozo

Abstract excerpt

Streptomycin has been an important drug for the treatment of tuberculosis since its discovery in 1944. But numerous strains of Mycobacterium tuberculosis, the bacterial pathogen that causes tuberculosis, are now streptomycin resistant. Although such resistance is often mediated by mutations within rrs, a 16S rRNA gene or rpsL, which encodes the ribosomal protein S12, these mutations are found in a limited...

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PMID: 17238915
DOI: 10.1111/j.1365-2958.2006.05585.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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