Article
Screening for streptomycin resistance-conferring mutations in Mycobacterium tuberculosis clinical isolates from Poland.
PloS one - 1 Jan 2014
Jagielski Tomasz, Ignatowska Helena, Bakuła Zofia, Dziewit Łukasz, Napiórkowska Agnieszka, Augustynowicz-Kopeć Ewa, Zwolska Zofia, Bielecki Jacek
Abstract excerpt
Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA, ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are considered to be involved in conferring resistance to streptomycin (STR) in Mycobacterium tuberculosis. The aim of this study was to investigate the spectrum and frequency of these mutations in M. tuberculosis clinical isolates, both resistant and...
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