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Article

Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism.

Antimicrobial agents and chemotherapy - 1 Aug 2008

Spies Fernanda S, da Silva Pedro E Almeida, Ribeiro Marta O, Rossetti Maria Lucia, Zaha Arnaldo

Abstract excerpt

The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.

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Identifiers

PMID: 18541729
DOI: 10.1128/AAC.01570-07
PMCID: PMC2493096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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