Article
Mutations in gidB confer low-level streptomycin resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Jun 2011
Wong Sharon Y, Lee Jong Seok, Kwak Hyun Kyung, Via Laura E, Boshoff Helena I M, Barry Clifton E
Abstract excerpt
The global threat posed by drug-resistant strains of Mycobacterium tuberculosis demands a greater understanding of the genetic basis and molecular mechanisms that govern how such strains develop resistance against various antituberculous drugs. In this report, we examine a new genetic basis for resistance to one of the oldest and most widely used second-line drugs employed in tuberculosis therapy, streptomycin...
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