Article
Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype.
Journal of clinical microbiology - 1 Jul 2013
Villellas Cristina, Aristimuño Liselotte, Vitoria María-Asunción, Prat Cristina, Blanco Silvia, García de Viedma Darío, Domínguez José, Samper Sofía, Aínsa José A
Abstract excerpt
The Mycobacterium tuberculosis pandemic is a major health problem, further complicated by an increasing incidence of drug-resistant isolates and the existence of highly transmissible strains, such as those in the Beijing family. Streptomycin (STR)-resistant M. tuberculosis clinical isolates have been analyzed to look for mutations in the rpsL, rrs, and gidB genes. In addition, the Rv1258c gene, which encodes Tap,...
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