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Molecular analysis of streptomycin-resistance associating genes in Mycobacterium tuberculosis isolates from Nepal.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2020

Shrestha Dipti, Maharjan Bhagwan, Thida Oo Nan Aye, Isoda Norikazu, Nakajima Chie, Suzuki Yasuhiko

Abstract excerpt

Mutation in rpsL (encoding ribosomal protein S12), rrs (encoding 16S ribosomal RNA) and gidB (encoding 7-methylguanosine methyltransferase) are associated with resistance to streptomycin (STR), which is used for the treatment of multi-drug resistant tuberculosis (MDR-TB) in Nepal. The aim of our study is to analyze the correlation between mutations in the target genes and STR-resistance in 197 Mycobacterium...

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PMID: 32829153
DOI: 10.1016/j.tube.2020.101985

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