Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability.

Neoplasia (New York, N.Y.) - 1 Feb 2005

Thorstensen Lin, Lind Guro E, Løvig Tone, Diep Chieu B, Meling Gunn I, Rognum Torleiv O, Lothe Ragnhild A

Abstract excerpt

An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding beta-catenin), AXIN2, TCF4, and WISP3] and three genes indirectly affecting this pathway [CDH1 (encoding E-cadherin), PTEN, and TP53]. APC and TP53 mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to Insulin-Like Growth Factor Binding Proteins

Share to Phosphoric Monoester Hydrolases

Share to Ploidies

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 15802015
DOI: 10.1593/neo.04448
PMCID: PMC1501125

Genes

APC
AXIN2
PTEN
TCF4
CDH1
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability.PMID 15802015Read ↗

Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.Semantic proximity Read ↗

A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Genome-wide differences between microsatellite stable and unstable colorectal tumors.Semantic proximity Read ↗

DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instabilitySemantic proximity Read ↗

Frequent alterations of the beta-catenin and TCF-4 genes, but not of the APC gene, in colon cancers with high-frequency microsatellite instability.Semantic proximity Read ↗

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.Semantic proximity Read ↗

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability.Semantic proximity Read ↗

Molecular Drivers of Tumor Progression in Microsatellite Stable <i>APC</i> Mutation-Negative Colorectal CancersSemantic proximity Read ↗

Chromosomally and microsatellite stable colorectal carcinomas without the CpG island methylator phenotype in a molecular classification.Semantic proximity Read ↗

Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways.Semantic proximity Read ↗

The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.