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Systematic CpG Islands Methylation Profiling of Genes in the Wnt Pathway in Epithelial Ovarian Cancer Identifies Biomarkers of Progression-Free Survival

2 Apr 2011

Abstract excerpt

PURPOSE: Wnt pathways control key biological processes that potentially impact on tumor progression and patient survival. We aimed to evaluate DNA methylation at promoter CpG islands (CGI) of Wnt pathway genes in ovarian tumors at presentation and identify biomarkers of patient progression-free survival (PFS). EXPERIMENTAL DESIGN: Epithelial ovarian tumors (screening study n = 120, validation study n = 61),...

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Share to Epigenetics and DNA Methylation
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 21459799
DOI: 10.1158/1078-0432.ccr-10-3021

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