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Article

Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer.

Neoplasia (New York, N.Y.) - 1 Jul 2007

Kawasaki Takako, Nosho Katsuhiko, Ohnishi Mutsuko, Suemoto Yuko, Kirkner Gregory J, Dehari Reiko, Meyerhardt Jeffrey A, Fuchs Charles S, Ogino Shuji

Abstract excerpt

The WNT/beta-catenin (CTNNB1) pathway is commonly activated in the carcinogenic process. Cross-talks between the WNT and cyclooxygenase-2 (COX-2 or PTGS2)/prostaglandin pathways have been suggested. The relationship between beta-catenin activation and microsatellite instability (MSI) in colorectal cancer has been controversial. The CpG island methylator phenotype (CIMP or CIMP-high) with widespread promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 17710160
DOI: 10.1593/neo.07334
PMCID: PMC1939932

Genes

PTGS2
BRAF
CRABP1
CTNNB1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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