Article
Reduced gonadotropin responses in a novel clonal strain of Leydig tumor cells established by transfection of MA-10 cells with a mutant gene of the type I regulatory subunit of the cAMP-dependent protein kinase.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1990
Wang H Y, Ascoli M
Abstract excerpt
Although it is clear that cAMP is an important mediator of the actions of LH/CG in Leydig cells, recent studies from several laboratories have shown that the functions of Leydig cells can also be modulated by hormones and growth factors that do not appear to use cAMP as a second messenger. Thus, in order to increase our understanding of the importance of cAMP as a modulator of the functions of Leydig cells we...
Topics
- Animals
- Chorionic Gonadotropin
- Clone Cells
- Cyclic AMP
- Enzyme Activation
- Genes, Regulator
- Gonadotropins
- Leydig Cell Tumor
- Mice
- Mutation
- Protein Kinases