Article
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Journal of cellular physiology - 1 Jan 1995
Krolczyk A J, Bear C E, Lai P F, Schimmer B P
Abstract excerpt
In order to evaluate the importance of cAMP and cAMP-dependent protein kinase (cAMPdPK) in the regulation of chloride efflux via the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, Caco-2, human colonic carcinoma cells were transfected with an expression vector encodi...
Topics
- Carbachol
- Chloride Channels
- Colforsin
- Colonic Neoplasms
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Dinoprostone
- Enzyme Activation
- Humans
- Isoproterenol
- Membrane Proteins
- Mutation
- Second Messenger Systems
- Transformation, Genetic
- Tumor Cells, Cultured
- Vasoactive Intestinal Peptide